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12-year results of the phase III SOFT trial show a maintained disease-free survival benefit

Adjuvant Endocrine Therapy and Ovarian Suppression for Premenopausal Patients With Hormone Receptor-Positive Breast Cancer: 12-Year Results of the SOFT Trial


As reported in the Journal of Clinical Oncology by Prudence A. Francis, MD, and colleagues, 12-year results of the phase III SOFT trial show a maintained disease-free survival benefit with the addition of ovarian function suppression to adjuvant tamoxifen in premenopausal patients with hormone receptor-positive breast cancer. Clinically meaningful absolute improvements in overall survival were observed with the addition of ovarian function suppression to tamoxifen or exemestane in subgroups of high-risk patients.


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